≡
Acute toxicity means serious adverse health effects (i.e., lethality) occurring after a single or short-term oral, dermal or inhalation exposure to a substance or mixture.
| ● | Acute oral toxicity, category 1 | Acute Tox. 1: H300 |
| ● | Acute oral toxicity, category 2 | Acute Tox. 2: H300 |
| ● | Acute oral toxicity, category 3 | Acute Tox. 3: H301 |
| ● | Acute oral toxicity, category 4 | Acute Tox. 4: H302 |
| ● | Acute dermal toxicity, category 1 | Acute Tox. 1: H310 |
| ● | Acute dermal toxicity, category 2 | Acute Tox. 2: H310 |
| ● | Acute dermal toxicity, category 3 | Acute Tox. 3: H311 |
| ● | Acute dermal toxicity, category 4 | Acute Tox. 4: H312 |
| ● | Acute inhalation toxicity, category 1 | Acute Tox. 1: H330 |
| ● | Acute inhalation toxicity, category 2 | Acute Tox. 2: H330 |
| ● | Acute inhalation toxicity, category 3 | Acute Tox. 3: H331 |
| ● | Acute inhalation toxicity, category 4 | Acute Tox. 4: H332 |
Skin corrosion means the production of irreversible damage to the skin; namely, visible necrosis through the epidermis and into the dermis occurring after exposure to a substance or mixture.
Skin irritation means the production of reversible damage to the skin occurring after exposure to a substance or mixture. (CLP, Annex I, 3.2.1).
| ● | Skin corrosion, sub-category 1A | Skin Corr. 1A: H314 |
| ● | Skin corrosion, sub-category 1B | Skin Corr. 1B: H314 |
| ● | Skin corrosion, sub-category 1C | Skin Corr. 1C: H314 |
| ● | Skin corrosion, category 1 | Skin Corr. 1: H314 |
| ● | Skin irritation, category 2 | Skin Irrit. 2: H315 |
Serious eye damage means the production of tissue damage in the eye, or serious physical decay of vision, which is not fully reversible, occurring after exposure of the eye to a substance or mixture.
Eye irritation means the production of changes in the eye, which are fully reversible, occurring after the exposure of the eye to a substance or mixture. (CLP, Annex I, 3.3.1).
| ● | Serious eye damage, category 1 | Eye Dam. 1: H318 |
| ● | Eye irritation, category 2 | Eye Irrit. 2: H319 |
Respiratory sensitisation means hypersensitivity of the airways occurring after inhalation of a substance or a mixture.
Skin sensitisation means an allergic response occurring after skin contact with a substance or a mixture. (CLP, Annex I, 3.4.1).
| ● | Respiratory sensitisation, category 1 | Resp. Sens. 1: H334 |
| ● | Respiratory sensitisation, sub-category 1A | Resp. Sens. 1A: H334 |
| ● | Respiratory sensitisation, sub-category 1B | Resp. Sens. 1B: H334 |
| ● | Skin sensitisation, category 1 | Skin Sens. 1: H317 |
| ● | Skin sensitisation, sub-category 1A | Skin Sens. 1A: H317 |
| ● | Skin sensitisation, sub-category 1B | Skin Sens. 1B: H317 |
Germ cell mutagenicity means heritable gene mutations, including heritable structural and numerical chromosome aberrations in germ cells occurring after exposure to a substance or mixture. (CLP, Annex I, 3.5.1).
| ● | Germ cell mutagenicity, category 1A | Muta. 1A: H340 |
| ● | Germ cell mutagenicity, category 1B | Muta. 1B: H340 |
| ● | Germ cell mutagenicity, category 2 | Muta. 2: H341 |
Carcinogenicity means the induction of cancer or an increase in the incidence of cancer occurring after exposure to a substance or mixture. Substances and mixtures which have induced benign and malignant tumours in well performed experimental studies on animals are considered also to be presumed or suspected human carcinogens unless there is strong evidence that the mechanism of tumour formation is not relevant for humans. (CLP, Annex I, 3.6.1).
| ● | Carcinogenicity, category 1A | Carc. 1A: H350 |
| ● | Carcinogenicity, category 1A | Carc. 1A: H350i |
| ● | Carcinogenicity, category 1B | Carc. 1B: H350 |
| ● | Carcinogenicity, category 1B | Carc. 1B: H350i |
| ● | Carcinogenicity, category 2 | Carc. 2: H351 |
Reproductive toxicity means adverse effects on sexual function and fertility in adult males and females, as well as developmental toxicity in the offspring, occurring after exposure to a substance or mixture. The definitions presented below are adapted from those agreed as working definitions in IPCS/EHC Document No 225, Principles for Evaluating Health Risks to Reproduction Associated with Exposure to Chemicals. For classification purposes, the known induction of genetically based inheritable effects in the offspring is addressed in Germ Cell Mutagenicity (Section 3.5), since in the present classification system it is considered more appropriate to address such effects under the separate hazard class of germ cell mutagenicity.
In this classification system, reproductive toxicity is subdivided into two main headings:
| (a) | adverse effects on sexual function and fertility; |
| (b) | adverse effects on development of the offspring. |
Some reproductive toxic effects cannot be clearly assigned to either impairment of sexual function and fertility or to developmental toxicity. Nonetheless, substances and mixtures with these effects shall be classified as reproductive toxicants with a general hazard statement. (CLP, Annex I, 3.7.1).
| ● | Reproductive toxicity, category 1A | Repr. 1A: H360 |
| ● | Reproductive toxicity, category 1A | Repr. 1A: H360F |
| ● | Reproductive toxicity, category 1A | Repr. 1A: H360Fd |
| ● | Reproductive toxicity, category 1A | Repr. 1A: H360FD |
| ● | Reproductive toxicity, category 1A | Repr. 1A: H360D |
| ● | Reproductive toxicity, category 1A | Repr. 1A: H360Df |
| ● | Reproductive toxicity, category 1B | Repr. 1B: H360 |
| ● | Reproductive toxicity, category 1B | Repr. 1B: H360F |
| ● | Reproductive toxicity, category 1B | Repr. 1B: H360Fd |
| ● | Reproductive toxicity, category 1B | Repr. 1B: H360FD |
| ● | Reproductive toxicity, category 1B | Repr. 1B: H360D |
| ● | Reproductive toxicity, category 1B | Repr. 1B: H360Df |
| ● | Reproductive toxicity, category 2 | Repr. 2: H361 |
| ● | Reproductive toxicity, category 2 | Repr. 2: H361f |
| ● | Reproductive toxicity, category 2 | Repr. 2: H361fd |
| ● | Reproductive toxicity, category 2 | Repr. 2: H361d |
| ● | Category for effects on or via lactation | Lact.: H362 |
Specific target organ toxicity – single exposure means specific, non-lethal toxic effects on target organs occurring after a single exposure to a substance or mixture. All significant health effects that can impair function, both reversible and irreversible, immediate and/or delayed and not specifically addressed in sections 3.1 to 3.7 and 3.10 are included (see also section 3.8.1.6). (CLP, Annex I, 3.8.1).
| ● | Specific target organ toxicity - single exposure, category 1 | STOT SE 1: H370 |
| ● | Specific target organ toxicity - single exposure, category 2 | STOT SE 2: H371 |
| ● | Specific target organ toxicity - single exposure (respiratory tract irritation), category 3 | STOT SE 3: H335 |
| ● | Specific target organ toxicity - single exposure (narcotic effects), category 3 | STOT SE 3: H336 |
Specific target organ toxicity - repeated exposure means specific toxic effects on target organs occurring after repeated exposure to a substances or mixture. All significant health effects that can impair function, reversible and irreversible, immediate and/or delayed are included. However, other specific toxic effects that are specifically addressed in sections 3.1 to 3.8 and 3.10 are not included here. (CLP, Annex I, 3.9.1).
| ● | Specific target organ toxicity - repeated exposure, category 1 | STOT RE 1: H372 |
| ● | Specific target organ toxicity - repeated exposure, category 2 | STOT RE 2: H373 |
Aspiration hazard means severe acute effects such as chemical pneumonia, pulmonary injury or death occurring after aspiration of a substance or mixture. (CLP, Annex I, 3.10.1.3).
| ● | Aspiration hazard, category 1 | Asp. Tox. 1: H304 |
Endocrine disruptor means a substance or a mixture that alters one or more functions of the endocrine system and consequently causes adverse effects in an intact organism, its progeny, populations or subpopulations. (CLP, Annex I, 3.11.1.1 (a)).
| ● | Endocrine disruptor for human health, category 1 | ED HH 1: EUH380 |
| ● | Endocrine disruptor for human health, category 2 | ED HH 2: EUH381 |