Online mixture classification calculator

Generic cut-off values

Cut-off value means a threshold of any classified impurity, additive or individual constituent in ... a mixture, above which threshold these shall be taken into account for determining if ... the mixture ... shall be classified (CLP, Article 2(31)). Cut-off value indicates if the presence of a substance in mixture needs to be taken into account for the purposes of appropriate classification.

The generic cut-off values are listed in Table 1.1 of Annex I to CLP.

Hazard class	Generic cut-off values to be taken into account
Acute Toxicity:
- Category 1-3: Acute Tox. 1 Acute Tox. 2 Acute Tox. 3	0.1 %
- Category 4: Acute Tox. 4	1 %
Skin corrosion/Irritation: Skin Corr. 1A Skin Corr. 1B Skin Corr. 1C Skin Corr. 1 Skin Irrit. 2	1 % or < 1 % where relevant
Serious damage to eyes/Eye irritation: Eye Dam. 1 Eye Irrit. 2	1 % or < 1 % where relevant
Specific target organ toxicity, single exposure, Category 3: STOT SE 3	1 % or < 1 % where relevant
Aspiration toxicity: Asp. Tox. 1	1 %
Hazardous to Aquatic Environment:
- Acute Category 1: Aquatic Acute 1	0.1 % or < 0.1 % where relevant
- Chronic Category 1: Aquatic Chronic 1	0.1 % or < 0.1 % where relevant
- Chronic Category 2-4: Aquatic Chronic 2 Aquatic Chronic 3 Aquatic Chronic 4	1 %

If mixture consists of substances each present at a concentration below the cut-off limit and even if the sum of their concentrations is above this limit the mixture will not be classified for this category.

Other hand, if ingredient has a specific concentration limit (SCL) below cut-off value, at the same time ingredient's concentration in a mixture is below cut-off value but above SCL, such ingredient is taken into account and a mixture will be classified in such category.

M-factor

For substances where M-factor (Multiplying factor) has been set for 'Aquatic Acute 1: H400' and/or 'Aquatic Chronic 1: H410' the cut-off value is calculated using the below formula (CLP, Annex I, 4.1.3.1).

Cut-off =

0.1

For example, if substance is classified both as 'Aquatic Acute 1: H400' with M = 100 and as 'Aquatic Chronic 1: H410' with M = 1, the cut-off for 'Aquatic Acute 1: H400' equals to 0.001 % (0.1/100) and for 'Aquatic Chronic 1: H410' equals to 0.1 % (0.1/1).

The entity which places on the European Economic Area market substances as such, in mixture or in article is obliged to classify all substances, as well as to set M-factors for those classified as 'Aquatic Acute 1' and/or 'Aquatic Chronic 1'. As a consequence, if substance have no M-factor in Table 3 of Annex VI to CLP, it should be set to calculate classification.

M-factor is also used for calculation of Aquatic Acute and Aquatic Chronic classification in summation method (see section Hazardous to the aquatic environment ).

Example 1

Example 2

Example 3

Example 4

Example 5

Ingredient	Conc. % (w/w)	Classification	Does take into account for mixture classification?
Substance A	0.8	Skin Corr. 1: H314	No, because concentration is below the generic cut-off value 1 %.
Substance B	15.2	−	−
Water	84.0	−	−

Ingredient	Conc. % (w/w)	Classification	Does take into account for mixture classification?
Substance A	0.8	Skin Corr. 1: H314	No, because concentration is below the generic cut-off value 1 %.
Substance B	1.1	Acute Tox. 4: H302	Yes, because concentration is above generic cut-off value 1 %.
Substance C	0.07	Acute Tox. 3: H301	No, because concentration is below the generic cut-off value 0.1 %.
Water	98.03	−	−

Ingredient	Conc. % (w/w)	Classification	Does take into account for mixture classification?
Substance A	0.8	Skin Corr. 1: H314	No, because concentration is below the generic cut-off value 1 %.
		Aquatic Acute 1: H400	Yes, because concentration is above calculated generic cut-off value 0.1 % (0.1/1). Because there is no M-factor in Table 3 of Annex VI to CLP, it is decided to use M = 1.
Substance B	2.0	Acute Tox. 4: H302	Yes, because concentration is above generic cut-off value 1 %.
Substance C	0.07	Acute Tox. 3: H301	No, because concentration is below the generic cut-off value 0.1 %.
Substance D	0.06	Acute Tox. 3: H311	No, because concentration is below the generic cut-off value 0.1 %.
Substance E	0.09	Acute Tox. 3: H311	No, because concentration is below the generic cut-off value 0.1 %.
Substance F	0.8	Acute Tox. 3: H311	Yes, because concentration is above generic cut-off value 0.1 %.
		Aquatic Chronic 4: H413	No, because concentration is below the generic cut-off value 1 %.
Water	96.18	−	−

Ingredient	Conc. % (w/w)	Classification	M-factor	Does take into account for mixture classification?
Substance A	0.08	Skin Corr. 1: H314	10	No, because concentration is below the generic cut-off value 1 %. M-factor is not applied.
		Aquatic Acute 1: H400		Yes, because concentration is above the calculated cut-off value 0.01 % (0.1/10). M = 10 is applied to Aquatic Acute 1
		Aquatic Chronic 1: H410		Yes, because concentration is above the calculated cut-off value 0.01 % (0.1/10). M = 10 is applied to Aquatic Chronic 1.
Substance B	0.08	Aquatic Acute 1: H400	−	No, because concentration is below the calculated generic cut-off value 0.1 % (0.1/1). Because there is no M-factor for Aquatic Acute 1 in Table 3 of Annex VI to CLP, it is decided to use M = 1.
		Aquatic Chronic 1: H410		No, because concentration is below the calculated generic cut-off value 0.1 % (0.1/1). Because there is no M-factor for Aquatic Chronic 1 in Table 3 of Annex VI to CLP, it is decided to use M = 1.
Water	99.84	−	−	−

Ingredient	Conc. % (w/w)	Classification	Specific Conc. Limit	Does take into account for mixture classification?
Substance A	0.6	STOT SE 3: H335	STOT SE 3: H335: C ≥ 0.5 %	Yes, because concentration is above the specific conc. limit Though the concentration is below the cut-off value 1 % for STOT SE 3 it is above the specific conc. limit 0.5 %.
Substance B	0.9	STOT SE 3: H335	−	No, because concentration is below the generic cut-off value 1 %.
Substance C	1.2	STOT SE 3: H335	−	Yes, because concentration is above generic cut-off value 1 %.
Water	97.3	−	−