Following ingredients are classified as respiratory / skin sensitisers:

−	Substance A:   Skin Sens. 1: H317.
−	Substance E:   Skin Sens. 1: H317.

Cut-off limits

−	There is no generic cut-off limit for respiratory and skin sensitisation (CLP, Annex I, Table 1.1), therefore, any concentration of an ingredient with such classification is taken into account.

Specific and Generic concentration limits

−	Because no specific concentration limits are applied for substances A and E their concentrations should be compared to generic concentration limits.

Calculation of 'Skin Sens. 1'

−	Concentration of substance A is above the generic concentration limit 1.0 % (CLP, Annex I, Table 3.4.5). Because no sub-categorisation is required this leads to classification Skin Sens. 1 .
−	Concentration of substance E is above the generic concentration limit 1.0 % (CLP, Annex I, Table 3.4.5). Because no sub-categorisation is required this leads to classification Skin Sens. 1 .

Selection of hazard category

−	The mixture is classified as 'Skin Sens. 1'.

Selection of hazard statements

−	H317 corresponds to 'Skin Sens. 1'.

Selection of pictogram and signal word

−	Pictogram GHS07 and signal word 'Warning' correspond to 'Skin Sens. 1'.

Selection of precautionary statements

−	For H317 following precautionary statements are applied: P261, P272, P280, P302+P352, P333+P313, P321, P362+P364, P501.

Following ingredients are classified as carcinogens:

−	Substance A:   Carc. 2: H351.
−	Substance B:   Carc. 1B: H350.
−	Substance C:   Carc. 2: H351.
−	Substance D:   Carc. 1B: H350.

Cut-off limits

−	There is no generic cut-off limit for carcinogenicity (CLP, Annex I, Table 1.1), therefore, any concentration of an ingredient with such classification is taken into account.

Specific and Generic concentration limits

−	Substance D has specific concentration limit (SCL). Because SCL has a precedence over generic concentration limit, concentration of D must be compared to its SCL.
−	Because no specific concentration limits are applied for substances A, B and C, their concentrations must be compared to generic concentration limits.

Calculation of 'Carc. 1B'

−	Concentration of substance D is above its specific concentration limit 0.01 %. This leads to classification Carc. 1B .
−	Concentration of substance B is above the generic concentration limit 0.1 % (CLP, Annex I, Table 3.6.2). This leads to classification Carc. 1B .

Calculation of 'Carc. 2'

−	Concentration of substance A is above the generic concentration limit 1.0 % (CLP, Annex I, Table 3.6.2). This leads to classification Carc. 2 .
−	Concentration of substance C is above the generic concentration limit 1.0 % (CLP, Annex I, Table 3.6.2). This leads to classification Carc. 2 .

Selection of hazard category

−	Classification sub-category 'Carc. 1B' is more severe than 'Carc. 2', therefore, mixture is classified as 'Carc. 1B'.

Selection of hazard statements

−	H350 corresponds to 'Carc. 1B'.

Selection of pictogram and signal word

−	Pictogram GHS08 and signal word 'Danger' correspond to 'Carc. 1B'.

Selection of precautionary statements

−	For H350 following precautionary statements are applied: P201, P202, P280, P308+P313, P405, P501.

Following ingredients are classified as reproductive toxicants:

−	Substance B:   Repr. 1B: H360F.
−	Substance D:   Repr. 2: H361f.

Cut-off limits

−	There is no generic cut-off limit for reproductive toxicity (CLP, Annex I, Table 1.1), therefore, any concentration of an ingredient with such classification is taken into account.

Specific and Generic concentration limits

−	Because no specific concentration limits are applied to substances B and D their concentrations should be compared to generic concentration limits.

Calculation of 'Repr. 1B'

−	Concentration of substance B is above the generic concentration limit 0.3 % (CLP, Annex I, Table 3.7.2). This leads to classification Repr. 1B .

Calculation of 'Repr. 2'

−	Concentration of substance D is below the generic concentration limit 3.0 % (CLP, Annex I, Table 3.7.2). This does not lead to classification 'Repr. 2'.

Selection of hazard category

−	The mixture is classified as 'Repr. 1B'.

Selection of hazard statements

−	H360F is selected for category 'Repr. 1B' because of the substance B.

Selection of pictogram and signal word

−	Pictogram GHS08 and signal word 'Danger' correspond to 'Repr. 1B'.

Selection of precautionary statements

−	For H360F following precautionary statements are applied: P201, P202, P280, P308+P313, P405, P501.

Following ingredients are classified as specific target organ toxicity – repeated exposure (STOT RE):

−	Substance A:   STOT RE 1: H372.
−	Substance B:   STOT RE 1: H372 (respiratory and haematopoietic systems).
−	Substance C:   STOT RE 2: H373.
−	Substance D:   STOT RE 1: H372 (lung).
−	Substance E:   STOT RE 2: H373 (kidneys).

Cut-off limits

−	There is no generic cut-off limit for STOT RE (CLP, Annex I, Table 1.1), therefore, any concentration of an ingredient with such classification is taken into account.

Specific and Generic concentration limits

−	Because no specific concentration limits are applied for substances A, B, C and E, their concentrations must be compared to generic concentration limits.
−	Substance D has two specific concentration limits (SCLs). Because SCL has a precedence over generic concentration limit, concentration of D must be compared to its SCLs.

Calculation of 'STOT RE 1'

−	Concentration of substance A is below the generic concentration limit 10 % (CLP, Annex I, Table 3.9.4). This does not lead to classification 'STOT RE 1'.
−	Concentration of substance B is above the generic concentration limit 10 % (CLP, Annex I, Table 3.9.4). This leads to classification STOT RE 1 .
−	Concentration of substance D is below its specific concentration limit 0.1 % for 'STOT RE 1'. This does not lead to classification 'STOT RE 1'.

Calculation of 'STOT RE 2'

−	Concentration of substance A is between 1 % and 10 % of the generic concentration limit (CLP, Annex I, Table 3.9.4). This leads to classification STOT RE 2 .
−	Concentration of substance C is below the generic concentration limit 10 % (CLP, Annex I, Table 3.9.4). This does not lead to classification 'STOT RE 2'.
−	Concentration of substance D is between 0.01 % and 0.1 % of its specific concentration limit for 'STOT RE 2'. This leads to classification STOT RE 2 .
−	Concentration of substance E is above the generic concentration limit 10 % (CLP, Annex I, Table 3.9.4). This leads to classification STOT RE 2 .

Selection of hazard category

−	Classification category 'STOT RE 1' is more severe than 'STOT RE 2', therefore, mixture is classified as 'STOT RE 1'.

Selection of hazard statements

−	H372 corresponds to 'STOT RE 1'.
−	For mixtures there is no need to identify the target organs and routes of exposure on the label.

Selection of pictogram and signal word

−	Pictogram GHS08 and signal word 'Danger' correspond to 'STOT RE 1'.

Selection of precautionary statements

−	For H372 following precautionary statements are applied: P260, P264, P270, P314, P501.

Following ingredients are classified as hazardous to the aquatic environment:

−	Substance C:   Aquatic Chronic 2: H411.
−	Substance E:   Aquatic Acute 1: H400 / Aquatic Chronic 1: H410.

Cut-off limits

For 'Aquatic Acute 1' and 'Aquatic Chronic 1' cut-off limit is calculated according to formula ^0.1/_M (CLP, Annex I, 4.1.3.1), where M is M-factor.

−

There is no M-factor in Table 3 of Annex VI to CLP established for substance E. Person responsible for classification decided to use M = 1 for both 'Aquatic Acute 1' and 'Aquatic Chronic 1'. Concentration of substance E is above 0.1 % (0.1/1), therefore, it is taken into account for calculation of both 'Aquatic Acute 1' and 'Aquatic Chronic 1'.

For Aquatic Chronic categories 2-4 the generic cut-off limit 1 % is applied (CLP, Annex I, Table 1.1):

−	Concentration of substance C is above 1 %, therefore, it is taken into account for calculation of 'Aquatic Chronic 2'.

Specific and Generic concentration limits

Neither specific nor generic concentration limits are applied for acute toxicity.

Calculation of 'Aquatic Acute 1'

−	Concentration of substance E must be multiplied by its M-factor. conc. E × M = 11.5 × 1 = 11.5 The obtained value is below 25 % (CLP, Annex I, 4.1.3.5.5.3.1 and Table 4.1.1). This does not lead to classification 'Aquatic Acute 1'.

Calculation of 'Aquatic Chronic 1'

−	Concentration of substance E must be multiplied by its M-factor. conc. E × M = 11.5 × 1 = 11.5 The obtained value is below 25 % (CLP, Annex I, 4.1.3.5.5.3.1 and Table 4.1.1). This does not lead to classification 'Aquatic Chronic 1'.

Calculation of 'Aquatic Chronic 2'

−

Concentration of substance E must be multiplied by its M-factor and multiplied by 10. Obtained value must later be summed with concentration of substance C. (M × 10 × conc. E) + conc. C = (1 × 10 × 11.5) + 5.7 = 120.7 The obtained value is above 25 %. This leads to classification Aquatic Chronic 2 .

Selection of hazard category

−	The mixture is classified as 'Aquatic Chronic 2'.

Selection of hazard statements

−	H411 corresponds to 'Aquatic Chronic 2'.

Selection of pictogram and signal word

−	Pictogram GHS09 corresponds to 'Aquatic Chronic 2'. No signal word applies.

Selection of precautionary statements

−	For H411 following precautionary statements are applied: P273, P391, P501.

According to Article 20(3) of CLP if both signal words are applied, 'Danger' is used.